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The results of the clinical trials that have examined the effects of selenium supplementation on thyroid autoimmunity in pregnant women have also been controversial [84, 85], and the latest ATA guidelines recommends against selenium supplementation in pregnant women [86]

The fundamental reason for this widespread ineffectiveness is poor **bioavailability**defined as the degree and rate at which an ingested nutrient is absorbed into the systemic circulation and becomes available at the site of biological action (i.e., the brain)

Onomoto K, Onoguchi K, Yoneyama M

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