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0521-2019-0009 Analysis of Receptor Mechanisms and Search for Means of Pharmacological Protection of the Central Nervous System in Impaired Brain Circulation and Cognitive Disturbances. Ethics declarations Conflict of interests

Authorship All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work, and have given final approval for the version to be published

Everything below is framed as the documented research protocol used on our own product pages for research and reference purposes only

In prolonged vasoplegia, the vasoconstrictive effect of intrinsic hormones (adrenaline, noradrenaline, arginine vasopressin, and angiotensin II) is reduced through a combination of hormone depletion, desensitization of adrenergic receptors, and smooth muscle cell hyperpolarisation [12]