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Moreover, expression of Cox4i2, Ndufa4l2 (complex I subunit), and Cox8b (complex IV subunit) was significantly reduced in mice approximately 2 months after Epas1 gene inactivation

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HSP is a highly conserved family of stress-inducible proteins, essential for cellular homeostasis, protecting against a variety of stress stimulus [83, 84], injury, and death and modulating the early inflammatory response to muscle injury [30, 31]

EV-derived VDAC1 protein activates autophagy by modulating AMPK/mTOR/p70S6K signaling to spread PTX resistance of GC cells Intracellular ATP levels were measured to further explore the specific pathways through which VDAC1 regulates autophagy