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Abbreviations CGRP: Calcitonin gene-related peptide CSD: Cortical spreading depolarization REFORM: Registry for Migraine ICHD-3: International Classification of Headache Disorders, 3rd edition IQR: Interquartile range FHM: Familial hemiplegic migraine TCC: Trigeminocervical complex BOLD: Blood oxygenation level-dependent References Stovner LJ, Nichols E, Steiner TJ (2018) Global, regional, and national burden of migraine and tension-type headache, 19902016: a systematic analysis for the global burden of Disease Study 2016