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Common adverse effects include nausea, flushing, muscle cramping, and headache, typically managed by slowing infusion rate

Excessive alcohol intake can reduce glutathione levels and increase oxidative stress

In addition, there is an overlap of pathological mechanisms and signaling pathways between the different forms of DILI

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caspases belong to the conserved family of cysteine proteases and can be categorized as either initiator caspases (caspase-8 and caspase-9) or executioner caspases (caspase-3, caspase-6, and caspase-7) according to their mechanism of action in apoptosis (Sahoo et al., 2023)