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Although the mechanism of action is not fully elucidated, the drug is thought to activate pathways in the brain that are involved in sexual responses

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Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.International Journal of Cancer2009;125:909917

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Thus, in a nutshell, it is possible that the initial DNA damage that predisposes melanocytes to malignant transformation and cytogenetic alterations that later promote actual malignant transformation of the initially transformed melanocytes may be driven by dysregulation in melanin biosynthesis and by the increased cellular content of melanin [10]