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The position and shape of the breakthrough curve can then be used to determine the equilibrium constants and number of binding sites of the applied analyte for the affinity ligand [13]

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Knocking out Nrf2 or using HO-1 antagonist reversed DOX-induced heart injury and death in mice, indicating that free iron released by heme degradation is a prerequisite for inducing heart injury

For example, novel small molecules that redirect undesirable secretory proteins to the ERAD, attenuate the evasion of ERAD by disease-causing mutants, or inhibit pathogen-mediated hijacking of ERAD could serve as useful reagents for treating a plethora of diseases

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