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This condition, known as degenerative spondylolisthesis, typically happens in the lower part of the spine, most commonly in the region joining the fourth and fifth lumbar vertebrae

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These modifications protect the peptide from exopeptidase-mediated degradation aminopeptidases at the N-terminus and carboxypeptidases at the C-terminus resulting in substantially improved metabolic stability in biological matrices

Water allows hydrolysis, deamidation, and microbial activity to proceed much faster