glutathione s-transferase deficiency The role of S-transferases in human disease pathogenesis and their current inhibitors Glutathione Participation in the Prevention

Ton et al., 2020

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This means that more methylfolate is diverted towards thymidine production, and less is available for methylation reactions.31 In particular, low methylfolate levels are associated with low glutathione.32 Glutathione is important for reducing oxidative stress and helping to halt the self-perpetuating peroxynitrite cycle

[DOI] [PubMed] [Google Scholar] Keppler D and Konig J (1997) Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver

In summary, DHODH and GPD2 prevent ferroptosis in the mitochondria by regulating the production of dihydroubiquinone in the inner mitochondrial membrane