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Thus, a high GSH content is beneficial for astrocytes and will thereby help to maintain the many important physiological functions that astrocytes have in the brain

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FIGURE 6 3 Discussion Pharmacokinetic evaluations are necessary and vital for the development of new drugs

Studies have shown that astragaloside IV could inhibit TGF-1/PI3K/Akt-induced hyperphosphorylation and downregulation of FOXO3a, prevent PF by inhibiting TGF-1/Smad pathway, downregulate the expression of Collagen I, fibronectin, and -SMA, and reduce inflammatory response and oxidative stress (Qian et al., 2018