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doi: 10.1016/j.intimp.2022.109061 138

Spelman T, Gray O, Trojano M et al (2014) Seasonal variation of relapse rate in multiple sclerosis is latitude dependent

This section highlights key examples of TCM-derived metabolites that have made significant strides toward clinical translation, including berberine, quercetin, and the polyherbal Qili Qiangxin capsule, focusing on trial data, outcomes, and safety profiles ( 3.1 Clinical evidence and translational successes As a single-metabolite supplement, berberine has been used in East Asia for metabolic and cardiovascular health for decades, and Western interest has increased in recent years (Song et al., 2020)