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Compromised GSH concentrations and diminished redox status in humans occurs over age 45, and A precipitous decline in GSH/GSSG redox occurs, along with a linear oxidation of cysteine/cystine redox state with age at a rate of 0.16mV/year over the entire age span (in plasma), GSH/GSSG redox was not oxidized prior to 45 years and subsequently was oxidized at a nearly linear rate of 0.7 mV/year

Onodera Y, Motohashi H, Takagi K, Miki Y, Shibahara Y, Watanabe M, Ishida T, Hirakawa H, Sasano H, Yamamoto M, Suzuki T (2014) NRF2 immunolocalization in human breast cancer patients as a prognostic factor

Y.WuC.et al

The mice even showed improve memory

Wang J, Wang GG