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Critically, the GSH/GSSG redox couple maintains the thiol groups of structural and enzymatic proteins in their reduced, functional state preventing irreversible oxidative cross-linking that would impair protein function

"Global, regional, national burden and gender disparity of cataract: findings from the global burden of disease study 2019"

The centrality of authors, institutions, and countries/regions was generally low, indicating a need for increased collaboration in the field

In the presence of H 2 O 2 it undergoes a partial irreversible inactivation due to the oxidation of cysteines, which is prevented by S -glutathionylation on at least three different Cys, including Cys499 and Cys587

Urlaub, G., Kas, E., Carothers, A