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There is a great deal of genetic variability in CYP family enzymatic activity, ranging from nonfunctional to increased function, representing another layer of complexity (45)

In particular, they are essential for the oxidative catabolism of long-chain fatty acids by shuttling them across the mitochondrial membrane from the cytosol into the mitochondrial matrix for oxidation and cellular energy production and thence for maintaining energy homeostasis in the human body

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10.1016/S0146-0005(99)80047-0

Consider treatment response and tolerability when selecting the maintenance dosage Cardiovascular risk reduction maintenance dose: Either 2.4 mg (recommended) or 1.7 mg once weekly, based on patient response and tolerance