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Supplementing with excessively high levels of B12 has been linked to other negative side effects

These vascular benefits are further augmented by increased BBB permeability, which facilitates the delivery of neurotrophic factors and metabolic substrates to the aging brain [214]

Eckfeldt, JH

GSSG accumulation shifts the glutathione pool toward a more oxidized state, although its interpretation remains context dependent

And I think, similar to this study, there are back pains that you can train through, and you can just modify things in the weight room and work your way through