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While the exact mechanism and involvement of oxidative stress in AD pathogenesis have yet to be elucidated, elevated levels of A and increased byproducts of cellular oxidation to lipids, proteins and nucleic acid are closely associated in patient populations (Gella and Durany, 2009

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Further, the development of "special early retirement" incentive programs under private pension plans has opened up additional opportunities for even earlier separation of new groups of older workers