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Unfortunately, factors such as genetics, environmental pollutants, and lifestyle habits can make achieving this goal difficult

NAC Supplements: Do the Pros Outweigh the Cons

For studies that did not provide SD data, only mean values are included

At therapeutic doses it is safe for most people, but acetaminophen metabolism uses glutathione directly, and chronic high dose use is the leading cause of acute liver failure in the United States precisely because it exhausts hepatic glutathione (PubMed PMID: 26041729)