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These responses can precede neurodegeneration and are significantly ameliorated in STING-knockout models, indicating that cGASSTING activation plays a pivotal role in -syn-induced neuroinflammation [170, 171]

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It also has known direct and indirect antioxidant effects in normal tissues [41], and it downregulates the pro-apoptotic proteins in ischemic reperfusion injury [42, 43]

Olszewski AJ and McCully KS (1993)

Common B12 deficiency symptoms include: Persistent fatigue and weakness Tingling or numbness in hands and feet Memory problems and difficulty concentrating Mood changes like irritability or depression Dizziness and balance issues Pale skin or yellowing of eyes Sore, red tongue Who is Most at Risk for B12 Deficiency