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Till SM, Li H-L, Miniaci MC, Kandel ER, Choi Y-B

Selank has been shown in studies to modulate monoamine neurotransmitters , including serotonin and dopamine , and impact brain-derived neurotrophic factor (BDNF) expression

LC and ME/CFS microbiomes incriminate low fiber diets that support low bacterial diversity with production of minimal Short Chain Fatty Acids (SCFAs), e.g., butyrates, GABA, and B vitamins

This observation has given rise to the spatiotemporal hypothesis, which proposes that, in addition to the nature of the NF1 mutation and additional genetic/epigenetic differences, the timing and the exact cell population that is undergoing loss of the second functional copy of NF1 are key factors that explain the overall phenotype

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