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A co-culture model of chicken satellite cells and intramuscular adipocytes showed that TIMP2 could promote IMF deposition through the ECMreceptor interaction signaling pathway [68]

It is also independently associated with abnormal lipid metabolism as well as an increased risk of cardiovascular and cerebrovascular disease compared to E3 and E2 alleles (Belloy et al., 2019

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In highly trained individuals with already optimized nutrition, the effects may be more subtle and mostly related to recovery or endurance rather than dramatic performance increases

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