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Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids J Affect Disord 1996

Nature 630 , 493500 (2024)

This was observed with MC4-NN20453 which caused pigmentation-related AEs in the clinic as a result of its strong MC1R agonism from high sustained systemic exposures (26, 55, 57)

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These findings suggest that prolonged use of sulindac may lead to neurotoxicity during CNS development