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We calculated absolute and relative changes, relative to counterfactual estimates

These promising results were more pronounced at the high dose of EMPA (3 mg/kg) than at the lower dose (1 mg/kg), which indicated that EMPA may exert its effects in a dose-dependent manner

It is generated when molecular oxygen is partially reduced to superoxide, hydrogen peroxide, lipid peroxides, or the hydroxyl and peroxyl radicals (Poursaitidis et al., 2017