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One adduct formed by non-enzymatic methyglyoxal glycation is the hydroimidazolone MG-H1, which is formed by modification of the arginine guanidino group (Fig

Mallick et al

Major factors contributing to the noncovalent recognition of small molecules by proteins and the binding strength between them include: Van der Waals forces, hydrogen bonds, ionic bonds, molecular reorganization, desolvation energy of the small molecule, hydrophobic interactions and, in certain instances, displacement energy for pre-existing bound ligands

This kind of enteric-triggered release protects acid-labile compounds through the stomach and targets their release to intestinal absorption sites