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The study suggests Polyscias fulva may exert its effects by regulating the HIF1A , ESR1 , EGFR , and CASP3 genes, promoting caspase-3 expression, and suppressing HIF-1, ER, and EGFR expression [Citation135]

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Studies have shown that thyroid autoimmunity is influenced by genetic variations in adhesion molecules (CD14, CD40), cytokines and their receptors, self-antigens, apoptosis-related gene products, and the promoter region of selenoprotein S (Klubo-Gwiezdzinska And Wartofsky 2022)

Furthermore, administration of ethanol led to a reduction in hepatic methionine and SAM levels, resulting in decreased DNA methylation and increased DNA strand breaks [23]

Steroids and peptides are different molecules and are subject to different regulations