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The rate is pH-dependent and accelerated at extremes of pH and higher temperatures

One paper [26] reviewing diabetic neuropathy included two RCTs [10,28] and concluded that ALC could relief neuropathic pain, while another paper reviewing HIV-associated neuropathy included one RCT [11] and suggested no superiority of ALC to placebo

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Modification Yeast imports precusor (3SH) Esterase enzyme forms thiol-acetate ester Export of thiol-acetate (3SHA) Release Yeast imports Glu-thiol precursor -Glutamyl transpeptidase enzyme converts Glu-thiol to Cys-thiol Yeast imports Cys-thiol precursor -Lyase enzyme cleaves cysteine from Cys-thiol precursor Yeast exports free volatile thiol Current research shows that higher IRC7 gene expression, -lyase activity, and thiol release are observed in lower nutrient conditions

Sehgal P, Gupta R, Choudhary K, Singh R BPC 157: A Promising Candidate for Cytoprotection and Tissue Repair