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Coffee enemas carry significant health risks including rectal perforation, severe electrolyte disturbances that can cause cardiac arrhythmias, caffeine toxicity, dehydration, thermal burns, and serious infections

Materials and methods Experimental design This study was conducted to examine these molecular foundations following the initial clinical trial (20212022), preceding broader validation

I've also read about once the process is overridden by saturation of B12 there's no going back to the natural process that was failing anyway

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De Rosa S, Eposito F, Carella C et al (2018) Transcoronary concentration gradients of circulating microRNAs in heart failure