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[29] Glutathione facilitates metabolism of xenobiotics

Structure of GPX4 U46C is based on crystal structure reported in this work

62,63 Excess iron is stored in unstable iron pools, which can increase due to metabolic imbalance, leading to increased ROS production through Fenton reactions

Starting from day 4, cells were maintained in S2 basal medium for 3 days, followed by S3 basal medium for 1 day

Objectives First line drugs such as Metformin (MTF) and Clomiphene citrate are associated with adverse effects such as multiple pregnancies, Ovary hyperstimulation syndrome, and gastric disturbances Phytochemicals are widely used alternatives among which CUR is widely reported and known to have similar effect to MTF Formulations of CUR in the PCOS treatment have a potential in alleviating the symptoms of PCOS Need for complementary therapies Preclinical investigations have established the potential of herbal drugs in treating PCOS, with polyphenols such as CUR, rutin, quercetin, catechin, gallic acid, cinnamon, and resveratrol showing effectiveness [15]