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Liberty: Priscilla Bautista Chahuiz (Degree)

When exposed to ROS, Nrf2 migrates from the cytoplasm to the nucleus where it leads to the upregulation of expression of several antioxidant and detoxification genes (e.g., GSTs, SODs, and HO-1), the downregulation of NF-B, and reduction in proinflammatory cytokines (e.g., IL-6 and IL-1)

doi: 10.1177/0269881115599386 80 KrupaAebkowskaAKondraciukMKaminskiKAKowalskaI

By stimulating insulin release and reducing glucagon secretion, GLP-1 efficiently lowers blood sugar levels while promoting a sense of fullness to support weight loss