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Kidney disease can affect the ability to metabolize vitamin B12

Face serums and creams: Clinical standard: 1-3% concentration Maximum typically used: 4% concentration Application: Once or twice daily Duration: Minimum 8-12 weeks for visible results Eye area products: Concentration: 1-2% (lower for sensitive periorbital skin) Application: Once daily, typically evening Amount: Pea-sized for both eyes Scalp solutions for hair: Concentration: 0.5% solution common Application: 1-2ml to affected areas once or twice daily Duration: 3-6 months minimum for meaningful changes Higher concentrations do not always mean better results with topicals

(Intrinsic factor is made by cells in the lining of the stomach and is needed for vitamin B12 to be absorbed.) Pernicious anaemia is the most common cause of B12 deficiency in Ireland

Directions for use: Shake well before use

PMID: 11237219 Cero C, et al