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Concurrently, the E3 ligase ZNRF2 tunes the ubiquitination of the auxiliary subunit SLC3A2 at K147, driving its plasma membrane translocation to maximize cystine import in lung adenocarcinoma, which can be therapeutically blocked by the synthetic peptide K147 [36]

These vitamins play a crucial role in maintaining nerve health and function

The identification of novel therapeutic strategies targeting amino acid pathways could allow for the emergence of new drugs and enhance the current therapeutic efficacy

Therefore, in the MSA brain, either syn aggregates spread from diseased neurons to oligodendroglia or diseased oligodendroglia ectopically express syn

doi: 10.1056/NEJMra1011035