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They need to be changed often and for the same reason

Flow is affected by the pressure gradient and the resistance fluid encounters between 2 points

Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)