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Crizotinib, as the first-generation ALK inhibitor, was the first to show marked improvements in PFS and overall response rates compared with conventional chemotherapy (76)

Intranasal administration is being explored for direct central nervous system delivery via olfactory and trigeminal nerve pathways, bypassing the blood-brain barrier and hepatic metabolism entirely

These values largely differ from those reported by other research groups (Table 2)

Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase