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10.1038/s41568-019-0216-7 21 HuangY.LiS.PanJ.SongC.ChenW.ZhangY

Phosphate-Based Cleavable Linking Groups Phosphate-based cleavable linking groups are cleaved by agents that degrade or hydrolyze the phosphate group

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This process is governed by a conserved and finely regulated enzymatic pathway involving Branched-Chain Aminotransferase 4 (BCAT4), Methylthioalkylmalate Synthase 1 (MAM1), and Cytochrome P450 Monooxygenase CYP79F1, with master transcriptional regulators like MYB28 orchestrating the overall flux ( Despite this expanding mechanistic understanding, a synthesis that adequately captures the full scope of SFNs journey and action is conspicuously absent