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This is completely abrogated in Nox2-deficient peritoneal macrophages (PM) and bone marrow-derived macrophages (BMDM) [30,58,232] establishing Nox2 as the exclusive source of extracellular ROS produced by macrophages in response to bacterial infection

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It is only when the concentration is low in relation to the C 50 that the concept of a half-life of drug effect has any meaning