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The same compound delivered topically through a serum, applied with microneedling, injected directly into the scalp, or injected subcutaneously into the abdomen will produce very different biological effects

To extract Rosa26 mito-roGFP2-Orp1 bone marrow cells from the bone marrow of Rosa26 mito-roGFP2-Orp1 mice, leg bones were centrifuged at 10,000 g for 15 s

PMID: 11311852

Eur J Med Chem 188:112040 Eghbaliferiz S, Farhadi F, Barreto GE, Majeed M, Sahebkar A (2020) Effects of curcumin on neurological diseases: focus on astrocytes

2 Superoxide, O 2 - , is toxic when in the protonated form, HO 2 , and can cause damage to the cells