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This article is republished from The Conversation under a Creative Commons license

This process of retrograde signaling or mitochondria talking to the nucleus is a newly recognized aspect of cell biology, and MOTS-c is one of the best examples we know of

For these reasons, the peptide is commonly included in anti-aging skin products [10, 11]

As of April 22, 2026, it was removed from FDA Category 2, but the FDA's Pharmacy Compounding Advisory Committee will not consider it for the 503A bulks list until the July 23, 2026 meeting

The tripeptide glycyl-L-histidyl-L-lysine binds to copper ions, creating a complex that your body recognizes as a wound-healing signal