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Advanced glycation end products accelerate rat vascular calcification through RAGE/oxidative stress

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52 Furthermore, the 5-Fluorouracil/protocatechuic acid synergy exerts anti-proliferative/pro-apoptotic effects and suppresses colony formation in AGS cells via P53 activation and Bcl-2 inhibition, demonstrating dual clinical advantages: reduced 5-Fluorouracil dosing requirements and enhanced apoptosis pathway targeting

The differentiation process was monitored daily using EVOS fluorescence microscopy to track the emergence of the differently marked mature epithelial types