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The main chemical reactions that take place near the chamber wall (cathode) are: 2H2O (l) + 2e- H2 (gas) + 2OH- (aq) Reactions in an alkaline solution (near the cathode) CO2(aq) + OH- (aq) HCO3 - (aq) HCO3 - (aq) + OH- (aq) CO3 2-(aq) + H20 (liquid) Ca2+(aq) Calcium ions may form Calcium Hydroxide: Ca(OH)2(Scale) Calcium carbonate: CaCO3 (scale) The chemical reactions that take place near the anode are: generate oxygen 4HO- O2(g) + 2H20 + 4e- Free chlorine Cl- e- Cl0 2Cl-(aq) Cl2(g) + 2e- Ozone O2 + 2HO- 2e- O3(g) + H2O Free radical OH- e- OH0 Hydrogen peroxide 2H2O 2 e- H2O2 + 2H+ Oxygen radical 2H2O 2e- O0 + 2 H+ EST pre-precipitates and discharges part of the scale in the form of solid inside the EST

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Moreover, isatuximab exhibits immunomodulatory effects by blocking the suppressive function of Tregs, consequently fostering NK- and T-cell-mediated antitumor immune responses [83]