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THC demonstrates antidepressant potential through anti-inflammatory and neuroprotective mechanisms, supporting its use as a safe augmentation strategy in MDD treatment

See the NEJM results, how it compares, and why it fell short of Novo's 25% target

10.14814/phy2.70385 12 BercovichB.StancovskiI.MayerA.BlumenfeldN.LaszloA.SchwartzA.et al (1997)

It generates second messengers that regulate calcium signaling and neurotransmitter release, fine-tuning the strength and efficiency of synaptic communication