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Discovery of the first highly selective antagonist of the GluK3 Kainate receptor subtype

Tomihara H, Carbone F, Perelli L, Huang JK, Soeung M, Rose JL, Robinson FS, Lissanu Deribe Y, Feng N, Takeda M, Inoue A, Poggetto ED, Deem AK, Maitra A, Msaouel P, Tannir NM , Draetta GF, Viale A, Heffernan TP, Bristow CA, Carugo A, Genovese G

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In previous studies, Nrf2 has been shown to play a central role in controlling the redox equilibrium of dendritic cells, thereby influencing antigen presentation activity (35)