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Tomlinson and Wheeler, 2017

Scheffzek K

Abnormal iron metabolism may cause iron accumulation in various tissues, including the brain, liver and pancreas, potentially inducing neurodegenerative changes such as neuronal loss, gliosis and mitochondrial dysfunction, which may clinically manifest as ataxia, dystonia and dementia (23)

These investigations support a deeper understanding of the biochemical substrates of cognition and facilitate the identification of novel targets for modulating neural circuit function