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For example, allopurinol can lead to kidney damage (12), febuxostat can increase the risk of cardiovascular diseases (13), and ibuprofen is associated with symptoms such as dizziness and drowsiness (14)

Author contributions SZ: Data curation, Formal analysis, Methodology, Software, Visualization, Writing original draft

The mitochondrial quality control system maintains mitochondrial function through mitophagy, biogenesis, and dynamics, while autophagyparticularly mitophagyis the primary mechanism for removing dysfunctional mitochondria ( During the progression of MAFLD, this regulatory circuitry is often disrupted

however, as the disease progresses these can often be seen with the naked eye, particularly when the iris is lightly pigmented and there is severe copper overload[13]

& Forloni, G