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In addition, the fourth line of defense may be activated by the reaction and generation of free radicals, which in turn induces the production and transport of corresponding antioxidant enzymes to the effective site and causes the formation of catalase and superoxide dismutase [32, 35]

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IGF-1 signalling is linked with the PI3K/Akt/mTOR pathway, which is heavily researched in skeletal muscle growth and repair biology

doi: 10.1371/journal.pone.0022031 290 VassilievV.HarrisZ

doi: 10.3390/antiox10010015 14 CaturanoADAngeloMMormoneARussoVMollicaMPSalvatoreTet al