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In PD, the relationship between iron and disease pathology is bidirectional [188]

(Mao et al., 2024)

Vitamin C is often taken together with L-glutathione as it helps support antioxidant activity and may assist in maintaining glutathione levels in the body

As discussed previously, excess oxidative stress in the endothelium primarily impacts NO production, both by direct conversion of superoxide anion and NO to peroxynitrite ( 4 ) or L-arginine ( 4 bioavailability also leads to increased superoxide formation by eNOS itself, furthering inhibition of endothelial NO signaling (Santhanam et al., 2012)