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However, the rise in cytoplasmic calcium concentration is transient, as elevated Ca 2+ is swiftly removed by two ATP-dependent calcium pumps: the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pumps Ca 2+ back to the ER, while the plasma membrane Ca 2+ ATPase (PMCA) expels Ca 2+ out of the cell, ensuring intracellular calcium balance (44)