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Trends Pharmacol Sci (2020) 41(9):598610

2314-C Fgl2-C3aR AXIS MEDIATED NEUTROPHIL EXTRACELLULAR TRAPS PROMOTE INTRAVASCULAR COAGULATION AND LIVER FIBROSIS IN NASH PROGRESSION Xitang Li 1 , Suping Hai 1 , Junjian Hu 1 , Qiang Gao 1 , Wenhui Wu 1 , Binghui Yu 1 , Erliang Xie 1 , Qin Ning 2 and Xiaojing Wang 3 , (1)State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, (2)Institute and Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, (3)Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology Background: Procoagulant imbalance was observed in non-alcoholic steatosis (NASH) patients with liver fibrosis, but the role of coagulation in NASH fibrosis remains largely unclear