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Gut microbiota owns the substitutable role (both the host nutrition and physiology) in amino acid metabolism, and the phenomenon shows the bidirectional process between amino acids and gut microbiota (Macfarlane and Macfarlane, 2012)

A good supplement sits alongside that conversation, never in place of it

Energy dependence: The transport process relies on the proton electrochemical gradient of the inner mitochondrial membrane to ensure the coupling of fatty acid transport and mitochondrial oxidative phosphorylation, maintaining the dynamic balance of energy metabolism

Mitochondrion 71:8392