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ER regulates neurobiological systems related to reproduction, such as those involved in sexual characteristics and maturation, while ER is implicated in the modulation of non-reproductive systems, including locomotion, memory and learning, anxiety and fear [40]

In contrast, antiangiogenic therapies combat cancer and malignancies, which require excess oxygen and nutrients to flourish

In US placebo-controlled clinical trials for Major Depressive Disorder, 12% to 16% of patients treated with PROZAC and 7% to 9% of patients treated with placebo reported anxiety, nervousness, or insomnia

no additional effect was observed when both curcumin and fluoxetine treatments were combined (103)