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Monitor patients closely, and perform serum liver testing prior to therapy and at frequent intervals thereafter (5.1) Fetal Risk, particularly neural tube defects, other major malformations, and decreased IQ (5.2, 5.3, 5.4) Pancreatitis, including fatal hemorrhagic cases (5.5) Recent Major Changes Indications and Usage for Depakote Depakote is an anti-epileptic drug indicated for: Treatment of manic episodes associated with bipolar disorder (1.1) Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures

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This first-in-human trial of hLB-001 gene editing therapy in MMA resulted in integration of the target gene in multiple participants without the use of nucleases

The causes and the effects of these abnormalities are topics of heated discussion within the research community.The focus of this chapter is to describe in greater detail the intra and intercellular role of mitochondria and the consequences of impaired mitochondrial function