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The way these molecules enter your system directly impacts their effectiveness at the cellular level

3) BDNF is not only released by glutamatergic presynaptic terminals and also acts as a retrograde messenger to inhibit the excitation of inhibitory dorsal horn neurons from the postsynaptic membrane (168)

10.1371/journal.pone.0015725 18 GarzonD

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In acute myeloid leukemia, the m6A methyltransferase METTL3 and the reader protein IGF2BP3 maintain high-level serine synthesis by recognizing and stabilizing the mRNAs of SSP-related genes including ATF4, PHGDH and PSAT1, meeting the high metabolic demands of cancer cells, particularly leukemia stem/initiating cells (93)